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Quantitative Brain MRI Lesion Load Predicts the Course of Clinically Isolated Syndromes Suggestive of Multiple Sclerosis Neurol 44:635-641, Felippi,M.,et al, 1994 See this aricle in Pubmed Article Abstract We performed semiautomated quantitative measurement of brain stem magnetic resonance imaging(MRI)abnormalities seen at presentation and at 5-year followup in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves,brainstem,or spinal cord suggestive of multiple sclerosis(MS).At followup,34(40%)had developed clinically definite and 4(5%)clinically probable MS.Patients who developed MS during followup had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at followup.Increasing initial lesion load correlated with a decreasing time to development of MS clinically(r=0.328,p<0.05).At followup,disability and brain lesion load were strongly correlated in patients who had developed MS.These results establish that MRI at presentation with clinically isolated syndromes suggestive of MS is useful in predicting the subsequent clinical course and the development of new MRI lesions.This suggests that quantitative brain MRI will be helpful in selecting patients with early clinical MS for treatment trials and for subsequent monitoring of their response to treatment.

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(click to filter results - removes previous filter) disability,neurological MRI MRI,abnormal multiple sclerosis multiple sclerosis,prognosis prognosis

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